Chemikalien
Further development of test methods for hormonally active pharmaceuticals and other substances
Sensor cell lines have been developed to monitor rapid non-genomic signalling cascades influenced by endocrine-active substances. These in-vitro bioassays were created by genetically modifying G-protein coupled estrogen receptor (GPER1) expressing cells to become artificial fluorescent signalosomes. Both GPER1 agonists and antagonistic compounds were used to characterize the respective sensor cell…weiterlesen