Chemikalien
Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints
For the evaluation of effects of hormone-active substances to fish, several test guidelines have been validated by the OECD which are included in the Conceptual Framework for Testing and Assessment of Endocrine Disruptors (OECD, 2010). In these tests, the assessment of physiological parameters is limited to the established biomarkers like vitellogenin or 11-keto testosterone in blo…weiterlesen